产品描述：玻玛西尼，也称为LY2835219，是一种口服的细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向CDK4（细胞周期蛋白D1）和CDK6（细胞周期素D3）细胞周期途径，具有潜在的抗肿瘤活性。LY2835219以低纳摩尔效力抑制CDK4和CDK6。LY2835219特异性抑制CDK4和6，从而抑制G1早期的视网膜母细胞瘤（Rb）蛋白磷酸化。抑制Rb磷酸化阻止CDK介导的G1-S期转变，从而阻止G1期的细胞周期，抑制DNA合成并抑制癌细胞生长。

产品名称: Abemaciclib free base
CAS#: 1231929-97-7 (free base)
分子式: C27H32F2N8
Exact Mass: 506.2718
分子量: 506.59
元素分析: C, 64.01; H, 6.37; F, 7.50; N, 22.12

Synonym: LY2835219; LY2835219; LY 2835219; Abemaciclib.

IUPAC/Chemical Name: N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine

InChi Key: UZWDCWONPYILKI-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)

SMILES Code: CC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0-4 C for short term (weeks), and -20 C for long term (months)

HS Tariff Code: 2934.99.9001