产品描述：阿卡替尼，也称为ACP-196，是一种口服的布鲁顿酪氨酸激酶（BTK）抑制剂，具有潜在的抗肿瘤活性。给药后，ACP-196抑制BTK的活性并阻止B细胞抗原受体（BCR）信号通路的激活。这防止了B细胞激活和BTK介导的下游生存途径的激活。这导致抑制过表达BTK的恶性B细胞的生长。BTK是src相关的细胞质酪氨酸激酶BTK/Tec家族的成员，在B细胞恶性肿瘤中过表达；它在B淋巴细胞的发育、活化、信号传导、增殖和存活中起重要作用。

产品名称: Acalabrutinib (ACP-196)
CAS#: 1420477-60-6 (free base)
分子式: C26H23N7O2
Exact Mass: 465.19132
分子量: 465.52
元素分析: C, 67.08; H, 4.98; N, 21.06; O, 6.87

Synonym: ACP-196; ACP196; ACP 196; Acalabrutinib

IUPAC/Chemical Name: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

InChi Key: WDENQIQQYWYTPO-IBGZPJMESA-N

InChi Code: InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1

SMILES Code: O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001