产品描述：维罗非尼也称为PLX4032、RG7204或RO5185426，是一种口服生物利用性、ATP竞争性的BRAF（V600E）激酶小分子抑制剂，具有潜在的抗肿瘤活性。Vemurafenib于2011年8月17日获得FDA批准用于 晚期黑色素瘤。Vemuraffenib选择性地结合BRAF（V600E）激酶的ATP结合位点并抑制其活性，这可能导致抑制表达BRAF的肿瘤细胞下游过度激活的MAPK信号通路并降低肿瘤细胞增殖。

产品名称: Vemurafenib
CAS#: 918504-65-1
分子式: C23H18ClF2N3O3S
Exact Mass: 489.07255
分子量: 489.92
元素分析: C, 56.39; H, 3.70; Cl, 7.24; F, 7.76; N, 8.58; O, 9.80; S, 6.54

Synonym: PLX4032; PLX 4032; PLX-4032; RG7204 ; RG7204 ; RG 7204 ; RO5185426; RO 5185426 RO5185426 Vemurafenib; Brand name: Zelboraf

IUPAC/Chemical Name: N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

InChi Key: GPXBXXGIAQBQNI-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)

SMILES Code: CCCS(=O)(NC1=CC=C(F)C(C(C2=CNC3=NC=C(C4=CC=C(Cl)C=C4)C=C32)=O)=C1F)=O

Appearance: White to off-white crystalline solid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001