产品描述：伯舒替尼，也称为SKI-606，是一种合成的喹诺酮衍生物和双激酶抑制剂，靶向具有潜在抗肿瘤活性的Abl和Src激酶。与伊马替尼不同，博苏替尼抑制Abl和Src激酶的自磷酸化，从而抑制细胞生长和凋亡。由于其双重作用机制，该药物可能在耐药CML疾病、其他髓系恶性肿瘤和实体瘤中具有活性。Abl激酶在异常Bcr-Abl融合蛋白的存在下上调，该蛋白通常与慢性粒细胞白血病（CML）相关。特异性Src激酶的过度表达也与伊马替尼耐药CML表型相关。博苏替尼于2012年获批。

产品名称: Bosutinib
CAS#: 380843-75-4 (free base)
分子式: C26H29Cl2N5O3
分子量: 530.44
元素分析: C, 58.87; H, 5.51; Cl, 13.37; N, 13.20; O, 9.05

Synonym: SKI606; SKI 606; SK-I606. SK 606; SK-606; SK606; KIN 001-160; KIN001-160; KIN-001-160; KIN 001160; KIN-001160; KIN001160; Bosutinib; Brand name: Bosulif.

IUPAC/Chemical Name: 4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile

InChi Key: UBPYILGKFZZVDX-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

SMILES Code: N#CC1=C(NC2=CC(OC)=C(Cl)C=C2Cl)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1

Appearance: Pale yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001