产品描述：舒尼替尼游离碱是一种口服小分子多靶向受体酪氨酸激酶（RTK）抑制剂。2006年1月26日，舒尼替尼苹果酸盐被FDA批准用于RCC和抗伊马替尼GIST。舒尼替尼可通过靶向多受体酪氨酸激酶（RTK）抑制细胞信号传导。因此，同时抑制这些靶点可减少blood vessel形成并触发癌细胞凋亡，从而导致cancer缩小。舒尼替尼还抑制CD117（c-KIT），CD117是一种受体酪氨酸激酶（当被突变不当激活时）驱动大多数胃肠道间质细胞cancer。

产品名称: Sunitinib free base
CAS#: 557795-19-4 (free base)
分子式: C22H27FN4O2
分子量: 398.48
元素分析: C, 66.31; H, 6.83; F, 4.77; N, 14.06; O, 8.03

IUPAC/Chemical Name: (Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

InChi Key: WINHZLLDWRZWRT-ATVHPVEESA-N

InChi Code: InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

SMILES Code: CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C2/C3=C(C=CC(=C3)F)NC2=O)C

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001