Description: 瑞博西尼，也称为LEE011，是一种口服的细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向细胞周期蛋白D1/CDK4和细胞周期蛋白D3/CDK6细胞周期途径，具有潜在的抗肿瘤活性。CDK4/6抑制剂LEE011特异性地抑制CDK4和6，从而抑制视网膜母细胞瘤（Rb）蛋白磷酸化。抑制Rb磷酸化阻止CDK介导的G1-S期转变，从而阻止G1期的细胞周期，抑制DNA合成并抑制癌细胞生长。在某些类型的癌症中，CDK4/6的过度表达会导致细胞周期失调。

产品名称: Ribociclib Free Base
CAS#: 1211441-98-3 (free base)
分子式: C23H30N8O
Exact Mass: 434.25426
分子量: 434.54
元素分析: C, 63.57; H, 6.96; N, 25.79; O, 3.68

Synonym: LEE011; LEE-011. LEE 011; Ribociclib; Kisqali.

IUPAC/Chemical Name: 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

InChi Key: RHXHGRAEPCAFML-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)

SMILES Code: O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001