产品描述：尼罗替尼，也称为AMN107，是一种小分子酪氨酸激酶抑制剂，被批准用于 伊马替尼耐药的慢性粒细胞白血病。在结构上与伊马替尼有关，它是基于Abl-伊马替尼复合物的结构开发的，以解决伊马替尼克不耐受和耐药性。尼罗替尼是一种选择性Bcr-Abl激酶抑制剂，在抑制Bcr-Alb酪氨酸激酶活性和Bcr-Abl表达细胞增殖方面比伊马替尼强10-30倍。诺利替尼由诺华公司开发，以商品名Tasigna出售。

产品名称: Nilotinib free base
CAS#: 641571-10-0 (free base)
分子式 C28H22F3N7O
分子量: 529.53
元素分析: C, 63.51; H, 4.19; F, 10.76; N, 18.52; O, 3.02

Synonym: Nilotinib free base; AMN 107; AMN107; AMN-107; Nilotinib; US brand name: Tasigna.

IUPAC/Chemical Name: 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-{(4-(pyridin-3-yl)pyrimidin-2-yl)amino}benzamide

InChi Key: HHZIURLSWUIHRB-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)

SMILES Code: O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001