产品描述：吡昔替尼，也称为PLX-3397，是一种CSF1R抑制剂，Plexxikon正在开发IC50为20nM，用于 腱膜巨细胞瘤。它正在进行色素性绒毛结节性滑膜炎（PVNS）或肌腱鞘巨细胞瘤（GCT-TS）的3期临床试验。

产品名称: Pexidartinib (PLX3397)
CAS#: 1029044-16-3 (free base)
分子式: C20H15ClF3N5
Exact Mass: 417.09681
分子量: 417.81
元素分析: C, 57.49; H, 3.62; Cl, 8.49; F, 13.64; N, 16.76

Synonym: PLX3397; PLX-3397; PLX 3397; CML-261; CML 261; CML261; FP-113; FP 113; FP113; Pexidartinib; Turalio

IUPAC/Chemical Name: 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

InChi Key: JGWRKYUXBBNENE-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)

SMILES Code: FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO (20mg/ mL), not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001