产品描述：来那替尼也称为HKI-272或PB272，是一种口服的、不可逆的HER-2受体酪氨酸激酶抑制剂，具有潜在的抗肿瘤活性。奈拉替尼不可逆地与HER-2受体结合，从而减少细胞中的自磷酸化，显然是通过靶向受体ATP结合袋中的半胱氨酸残基。

产品名称: Neratinib
CAS#: 698387-09-6 (free base)
分子式: C30H29ClN6O3
Exact Mass: 556.19897
分子量: 557.04
元素分析: C, 64.68; H, 5.25; Cl, 6.36; N, 15.09; O, 8.62

Synonym: HKI272; HKI 272; HKI-272; PB272; PB 272; PB-272; Neratinib; Nerlynx

IUPAC/Chemical Name: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

InChi Key: JWNPDZNEKVCWMY-VQHVLOKHSA-N

InChi Code: InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+

SMILES Code: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001