产品描述：拉帕替尼是一种合成的口服活性喹唑啉，具有潜在的抗肿瘤活性。拉帕替尼可逆地阻断表皮生长因子受体（EGFR）、ErbB2、Erk-1和2以及AKT激酶的磷酸化；它还抑制人肿瘤细胞系和异种移植物中的细胞周期蛋白D蛋白水平。EGFR和ErbB2与各种肿瘤类型的生长有关。检查使用该药剂的活跃临床试验或封闭临床试验。

产品名称: Lapatinib (free base)
CAS#: 231277-92-2 (free base)
分子式: C29H26ClFN4O4S
Exact Mass: 580.13473
分子量: 581.06
元素分析: C, 59.94; H, 4.51; Cl, 6.10; F, 3.27; N, 9.64; O, 11.01; S, 5.52

Synonym: GSK572016; GSK-572016; GSK 572016; GW2016; GW-2016; GW 2016; Lapatinib. US brand name: Tykerb.

IUPAC/Chemical Name: N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine

InChi Key: BCFGMOOMADDAQU-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

SMILES Code: O=S(CCNCC1=CC=C(C2=CC3=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)N=CN=C3C=C2)O1)(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001