产品描述：吉列替尼，也称为ASP2215，是一种有效的FLT3/AXL抑制剂，对FLT3-ITD和FLT3-D835突变的AML表现出有效的抗白血病活性。在体外，在测试的78种酪氨酸激酶中，ASP2215在1nM时抑制FLT3、LTK、ALK和AXL激酶超过50%，FLT3的IC50值为0.29nM，大约比c-KIT强800倍，其抑制与骨髓抑制的潜在风险有关。ASP2215抑制携带FLT3-ITD的MV4-11细胞的生长，IC50值为0.92nM，同时抑制pFLT3、pAKT、pSTAT5、pERK和pS6。ASP2215可能在 AML中有潜在用途。

产品名称: Gilteritinib
CAS#: 1254053-43-4 (free base)
分子式: C29H44N8O3
Exact Mass: 552.35364
分子量: 552.71
元素分析: C, 63.02; H, 8.02; N, 20.27; O, 8.68

Synonym: ASP-2215; ASP2215; ASP 2215; Gilteritinib.

IUPAC/Chemical Name: 6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide.

InChi Key: GYQYAJJFPNQOOW-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

SMILES Code: O=C(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C(OC)=C3)N

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001