产品描述：达克替尼，也称为PF-299和PF-00299804；PF299804是酪氨酸激酶（ErbB家族）泛表皮生长因子受体（EGFR）家族的一种口服生物可利用、高选择性的 代小分子抑制剂，具有潜在的抗肿瘤活性。达科替尼特异性且不可逆地结合并抑制人EGFR亚型，导致抑制EGFR表达肿瘤细胞的增殖和诱导凋亡。EGFR在肿瘤细胞增殖和肿瘤血管形成中起主要作用，并且在各种肿瘤细胞类型中经常过度表达或突变。

产品名称: Dacomitinib
CAS#: 1110813-31-4 (free)
分子式: C24H25ClFN5O2
Exact Mass: 469.16808
分子量: 469.94
元素分析: C, 61.34; H, 5.36; Cl, 7.54; F, 4.04; N, 14.90; O, 6.81

Synonym: PF-00299804; PF00299804; PF 00299804; PF299804; PF-299804; PF 299804; PF-299; PF299; PF 299; Dacomitinib; Vizimpro;

IUPAC/Chemical Name: (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide

InChi Key: LVXJQMNHJWSHET-AATRIKPKSA-N

InChi Code: InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+

SMILES Code: O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC)/C=C/CN4CCCCC4

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001