产品描述：达帕菲尼，也称为GSK2118436，是一种口服生物可利用的B-raf（BRAF）蛋白抑制剂，具有潜在的抗肿瘤活性。达帕菲尼选择性地结合并抑制B-raf的活性，B-raf可以抑制含有突变BRAF基因的肿瘤细胞的增殖。B-raf属于丝氨酸/苏氨酸蛋白激酶的raf/mil家族，在调节MAP激酶/ERKs信号通路中发挥作用，该通路可能由于BRAF基因突变而被组成性激活。2013年5月29日，FDA批准了该药物。

产品名称: Dabrafenib
CAS#: 1195765-45-7 (free base)
分子式: C23H20F3N5O2S2
Exact Mass: 519.10105
分子量: 519.56
元素分析: C, 53.17; H, 3.88; F, 10.97; N, 13.48; O, 6.16; S, 12.34

Synonym: GSK2118436A ( Dabrafenib ); GSK 2118436A; GSK-2118436A; GSK2118436B ( Dabrafenib Mesylate ); GSK-2118436B; GSK 2118436B. Trade name: Tafinlar.

IUPAC/Chemical Name: N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

InChi Key: BFSMGDJOXZAERB-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)

SMILES Code: O=S(C1=C(F)C=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C(C)(C)C)=N3)=C2F)=O

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001