描述：Ceritinib也称为LDK378，是ALK1的选择性抑制剂，ALK1是一种在NSCLC中发现的靶点。在I期试验中，LDK378在78例间变性NSCLC激酶阳性（ALK+）NSCLC患者中显示出显著的临床反应，这些患者在克唑替尼期间或之后有进展，或之前未接受过克唑替尼。LDK378阻断ALK蛋白并阻止其向癌细胞发送生长信号，这可能会阻止cancer cells生长。Ceritinib于2014年4月获得批准。

产品名称: Ceritinib free base
CAS#: 1032900-25-6 (free base)
分子式: C28H36ClN5O3S
分子量: 558.14
元素分析: C, 60.25; H, 6.50; Cl, 6.35; N, 12.55; O, 8.60; S, 5.75

Synonym: LDK-378; LDK378; LDK 378; Ceritinib, brand name: Zykadia.

IUPAC/Chemical Name: 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

InChi Key: VERWOWGGCGHDQE-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)

SMILES Code: ClC1=CN=C(NC2=CC(C)=C(C3CCNCC3)C=C2OC(C)C)N=C1NC4=CC=CC=C4S(C(C)C)(=O)=O

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001