Description: α-Ketoglutaric acid is an α-keto acid and a rate-determining metabolic intermediate in the citric acid cycle in its conjugate base form, α-ketoglutarate. It is formed via oxidative decarboxylation of isocitrate by isocitrate dehydrogenase (IDH), oxidative deamination of glutamate by glutamate dehydrogenase, or by pyridoxal phosphate-dependent transamination. α-Ketoglutaric acid is decarboxylated to succinyl-CoA by α-ketoglutarate dehydrogenase, a rate limiting step in the citric acid cycle. It is a precursor of glutamine and glutamate, energy sources for enterocytes and various immune cells, and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development.

Name: α-KGA
CAS#: 22202-68-2
Chemical Formula: C5H6NaO5
Exact Mass:
Molecular Weight: 169.0878
Elemental Analysis: C, 35.52; H, 3.58; Na, 13.60; O, 47.31

Synonym: α-KGA; αKGA; α KGA; 2-Oxoglutaric Acid; 2 Oxoglutaric Acid; α-Ketoglutaric Acid; α Ketoglutaric Acid; α-Ketoglutaric Acid sodium salt; α Ketoglutaric Acid sodium salt;

IUPAC/Chemical Name: 2-oxopentanedioic acid, sodium salt

InChi Key: GPRYXSKURSLOCH-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);

SMILES Code: O=C(O)C(CCC(O)=O)=O.[Na]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001