Description: Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 μM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of non-24-hour sleep-wake disorder.

Name: Tasimelteon-d5
CAS#: 1962124-51-1
Chemical Formula: C15H14D5NO2
Exact Mass: 250.173
Molecular Weight: 250.3525
Elemental Analysis: C, 71.96; H, 9.66; N, 5.59; O, 12.78

Synonym: Tasimelteon-d5; Tasimelteon d5; BMS 214778-d5; BMS214778-d5; BMS 214778-d5;

IUPAC/Chemical Name: N-(((1R,2R)-2-(2,3-dihydrobenzofuran-4-yl)cyclopropyl)methyl)propanamide

InChi Key: PTOIAAWZLUQTIO-WILSWDKCSA-N

InChi Code: InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1/i1D3,2D2

SMILES Code: O=C(NC[C@@H]1C[C@]1(C2=C3C(OCC3)=CC=C2)[H])C([2H])(C([2H])([2H])[2H])[2H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001