Description: T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor that inhibits PCNA/PIP-box peptide interaction and causes DNA replication stress by stalling DNA replication forks. It inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. It also suppresses cancer cell growth.

Name: T2AA
CAS#: 1380782-27-3
Chemical Formula: C15H15I2NO3
Exact Mass: 510.9141
Molecular Weight: 511.09
Elemental Analysis: C, 35.25; H, 2.96; I, 49.66; N, 2.74; O, 9.39

Synonym: T2AA

IUPAC/Chemical Name: (S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)phenol

InChi Key: NKOSKXJRVWVXRI-JTQLQIEISA-N

InChi Code: InChI=1S/C15H15I2NO3/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12/h1-4,6-7,10,19-20H,5,8,18H2/t10-/m0/s1

SMILES Code: IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001