Description: SPL-334 is an inhibitor of S-nitrosoglutathione reductase. SPL-334 prevents weight loss, attenuating lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice.

Name: SPL-334
CAS#: 688347-51-5
Chemical Formula: C22H15N3O3S2
Exact Mass: 433.0555
Molecular Weight: 433.5
Elemental Analysis: C, 60.96; H, 3.49; N, 9.69; O, 11.07; S, 14.79

Synonym: SPL-334; SPL334; SPL 334

IUPAC/Chemical Name: 4-[[2-[(2-Cyanophenyl)methylsulfanyl]-4-oxothieno[3,2-d]pyrimidin-3-yl]methyl]benzoic acid

InChi Key: UWWSCLNCHCROLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H15N3O3S2/c23-11-16-3-1-2-4-17(16)13-30-22-24-18-9-10-29-19(18)20(26)25(22)12-14-5-7-15(8-6-14)21(27)28/h1-10H,12-13H2,(H,27,28)

SMILES Code: O=C(O)C1=CC=C(CN(C(SCC2=CC=CC=C2C#N)=NC3=C4SC=C3)C4=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001