Description: Rolofylline, aslo known as KW-3902, is an experimental diuretic which acts as a selective adenosine A1 receptor antagonist. Development of rolofylline was terminated on September 1, 2009, after the results of a large clinical trial (PROTECT) showed the drug to be no better than placebo for patients with acute heart failure. Participants given rolofylline did show some improvement in shortness of breath, but the drug did not prevent kidney damage or have any significant effect on overall treatment success. Rolofylline was also associated with a higher incidence of seizures and stroke.

Synonym: KW-3902; KW 3902; KW3902; Rolofylline

IUPAC/Chemical Name: 8-((2R,3as,5S,6as)-hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

InChi Key: PJBFVWGQFLYWCB-OYEQCZOJSA-N

InChi Code: InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-

SMILES Code: O=C(N1CCC)N(CCC)C2=C(NC([C@@]3([C@@H]4C5)C[C@H](C4)C[C@H]5C3)=N2)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001