产品描述：奥瑞替尼（Osimertinib，又称AZD-9291和Mereletinib）是第三代EGFR抑制剂，在临床前研究中显示出了前景，并为对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。AZD9291在临床前模型中具有高度活性，在动物模型中耐受性良好。它抑制激活和抗性EGFR突变，同时保留正常皮肤和肠道细胞中存在的正常形式的EGFR，从而减少当前可用药物的副作用。奥西美替尼于2015年11月获得FDA批准。

产品名称: Osimertinib free base
CAS#: 1421373-65-0 (free base)
分子式: C28H33N7O2
Exact Mass: 499.26957
分子量: 499.61
元素分析: C, 67.31; H, 6.66; N, 19.62; O, 6.40

Synonym: AZD9291; AZD 9291; AZD-9291; AZD-9291 freebase; Mereletinib; Osimertinib free base; trade name Tagrisso.

IUPAC/Chemical Name: N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

InChi Key: DUYJMQONPNNFPI-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

SMILES Code: C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O

Appearance: Brown to yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001