Description: NV-5138 is an orally and centrally active small-molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal cortex (mPFC) to mediate its rapid-acting antidepressant effects. A single oral dose of NV-5138 has been found to increase mTORC1 signaling and produce synaptogenesis in the mPFC and to induce rapid antidepressant effects in multiple animal models of depression.

Name: NV-5138
CAS#: 2095886-80-7
Chemical Formula: C7H13F2NO2
Exact Mass: 181.0914
Molecular Weight: 181.1828
Elemental Analysis: C, 46.40; H, 7.23; F, 20.97; N, 7.73; O, 17.66

Synonym: NV-5138; NV 5138; NV5138;

IUPAC/Chemical Name: Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-

InChi Key: HRFIMCJTDKEPPV-BYPYZUCNSA-N

InChi Code: InChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1

SMILES Code: O=C(O)[C@@H](N)CC(C)(C)C(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001