产品描述：米哚妥林，也称为PKC-412、PKC-412A和CGP 41251；是一种合成的吲哚咔唑多激酶抑制剂，具有潜在的抗血管生成和抗肿瘤活性。米德斯塔林抑制蛋白激酶Cα（PKCalpha）、血管内皮生长因子受体2（VEGFR2）、C-kit、血小板衍生生长因子受体（PDGFR）和FMS样酪氨酸激酶3（FLT3）酪氨酸激酶，这可能导致易感肿瘤中的细胞周期中断、增殖抑制、凋亡抑制和血管生成抑制。Midostaurin于2017年获得批准。

产品名称: Midostaurin
CAS#: 120685-11-2
分子式: C35H30N4O4
Exact Mass: 570.22671
分子量: 570.6371
元素分析: C, 73.67; H, 5.30; N, 9.82; O, 11.22

Synonym: PKC-412; PKC412; PKC 412; PKC412A; PKC-412A; PKC 412A; CGP41251; CGP 41251; CGP-41251; Midostaurin; Rydapt

IUPAC/Chemical Name: N-((5R,7R,8R,9S)-8-methoxy-9-methyl-16-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

InChi Key: BMGQWWVMWDBQGC-IIFHNQTCSA-N

InChi Code: InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1

SMILES Code: C[C@@]12[C@H](OC)[C@H](N(C(C3=CC=CC=C3)=O)C)C[C@H](N4C5=CC=CC=C5C6=C7C(CNC7=O)=C8C9=CC=CC=C9N2C8=C64)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not soluble in water.

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001