产品简介：厄达替尼，也称为JNJ-42756493，是一种有效且选择性的口服生物利用性泛成纤维细胞生长因子受体（FGFR）抑制剂，具有潜在的抗肿瘤活性。口服给药后，JNJ-42756493结合并抑制FGFR，这可能导致抑制FGFR相关信号转导途径，从而抑制FGFR过表达肿瘤细胞中的肿瘤细胞增殖和肿瘤细胞死亡。FGFR在许多肿瘤细胞类型中上调，是一种对肿瘤细胞增殖、分化和存活至关重要的受体酪氨酸激酶。

产品名称: Erdafitinib
CAS#: 1346242-81-6
分子式: C25H30N6O2
Exact Mass: 446.24302
分子量: 446.55
元素分析: C, 67.24; H, 6.77; N, 18.82; O, 7.17

Synonym: JNJ-42756493; JNJ 42756493; JNJ42756493; Erdafitinib

IUPAC/Chemical Name: N1-(3,5-dimethoxyphenyl)-N2-isopropyl-N1-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)ethane-1,2-diamine

InChi Key: OLAHOMJCDNXHFI-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3

SMILES Code: CC(NCCN(C1=CC(OC)=CC(OC)=C1)C2=CC=C3N=CC(C4=CN(C)N=C4)=NC3=C2)C

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001