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Encorafenib 康奈非尼 1269440-17-6
  • 品牌:MedKoo
  • 产地:美国
  • 货号:205852
  • cas:1269440-17-6
  • 发布日期: 2022-07-20
  • 更新日期: 2024-08-12
产品详请
产地 美国
品牌 MedKoo
货号 205852
用途 This product is for research use only, not for human or veterinary use.
包装规格 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g;
CAS编号 1269440-17-6
纯度 >98%%
是否进口

产品描述:康奈非尼,也称为LGX-818,是一种口服Raf激酶抑制剂,具有潜在的抗肿瘤活性。LGX818特异性抑制Raf激酶,一种Raf/丝裂原激活蛋白激酶(MEK)/细胞外信号相关激酶(ERK)信号通路中的丝氨酸/苏氨酸酶。通过抑制RAF/MEK/ERK信号通路的激活,LGX818的施用可能导致肿瘤细胞增殖的减少。

产品名称: Encorafenib
CAS#: 1269440-17-6
分子式: C22H27ClFN7O4S
Exact Mass: 539.15178
分子量: 540.01
元素分析: C, 48.93; H, 5.04; Cl, 6.57; F, 3.52; N, 18.16; O, 11.85; S, 5.94

Synonym: LGX818; LGX-818; LGX 818; Encorafenib.

IUPAC/Chemical Name: (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate.

InChi Key: CMJCXYNUCSMDBY-ZDUSSCGKSA-N

InChi Code: InChI=1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1

SMILES Code: O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001