Description: Axitinib sulfoxide is a major metabolite of Axitinib --- a VEGFR tyrosine kinase inhibitor. Axitinib may be useful in cancer therapy.

Name: Axitinib sulfoxide
CAS#: 1347304-18-0
Chemical Formula: C22H18N4O2S
Exact Mass: 402.115
Molecular Weight: 402.47
Elemental Analysis: C, 65.65; H, 4.51; N, 13.92; O, 7.95; S, 7.97

Synonym: AG-028458, Axitinib metabolite M12, Axitinib sulfoxide, PF-03482595

IUPAC/Chemical Name: Benzamide, N-methyl-2-((3-((1E)-2-(2-pyridinyl)ethenyl)-1H-indazol-6-yl)sulfinyl)

InChi Key: MAHSNFBPPYMWFB-FMIVXFBMSA-N

InChi Code: 1S/C22H18N4O2S/c1-23-22(27)18-7-2-3-8-21(18)29(28)16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

SMILES Code: CNC(=O)c1ccccc1S(=O)c2ccc3c(c2)[nH]nc3/C=C/c4ccccn4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001