ARN 14494-北京百奥创新科技有限公司

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ARN 14494

品牌：MedKoo

产地：美国

货号：565379

cas：1037837-27-6

发布日期： 2022-07-20
更新日期： 2024-08-12

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产地	美国
品牌	MedKoo
货号	565379
用途	This product is for research use only, not for human or veterinary use.
包装规格	10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 2.0g;
CAS编号	1037837-27-6
纯度	>98%%
是否进口	是

Description: ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

Synonym: ARN-14494; ARN 14494; ARN14494;

IUPAC/Chemical Name: 1-(1-(2-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl)piperidin-4-yl)-N-methyl-2-oxoindoline-5-carboxamide

InChi Key: TYZOOEYUTZDYPB-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H32N4O3/c1-25-24(31)16-5-6-21-19(11-16)12-22(29)28(21)20-7-9-26(10-8-20)15-23(30)27-13-17-3-2-4-18(17)14-27/h5-6,11,17-18,20H,2-4,7-10,12-15H2,1H3,(H,25,31)

SMILES Code: O=C(C1=CC2=C(N(C3CCN(CC(N4CC5C(CCC5)C4)=O)CC3)C(C2)=O)C=C1)NC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001