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- 品牌：MedKoo
- 产地：美国
- 货号：561105
- cas：1637771-14-2
- 发布日期： 2022-07-20
- 更新日期： 2024-08-12
| 产地 | 美国 |
| 品牌 | MedKoo |
| 货号 | 561105 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包装规格 | 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; |
| CAS编号 | 1637771-14-2 |
| 纯度 | >98%% |
| 是否进口 | 是 |
Description: Alobresib, also known as GS-5829, is a potent and selective BET inhibitor. GS-5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment. GS-5829 inhibited CLL cell proliferation and induced leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. IκBα modulation indicates that GS-5829 also inhibited NF-κB signaling. GS-5829-induced apoptosis resulted from an imbalance between positive (BIM) and negative regulators (BCL-XL) of the intrinsic apoptosis pathway.
Synonym: Alobresib; GS-5829; GS 5829; GS5829;
IUPAC/Chemical Name: [2-cyclopropyl-6-(3,5-dimethyl-1,2-oxazol-4-yl)-1H-benzimidazol-4-yl]di(pyridin-2-yl)methanol
InChi Key: CMSUJGUHYXQSOK-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H23N5O2/c1-15-23(16(2)33-31-15)18-13-19(24-20(14-18)29-25(30-24)17-9-10-17)26(32,21-7-3-5-11-27-21)22-8-4-6-12-28-22/h3-8,11-14,17,32H,9-10H2,1-2H3,(H,29,30)
SMILES Code: OC(C1=NC=CC=C1)(C2=C3N=C(C4CC4)NC3=CC(C5=C(C)ON=C5C)=C2)C6=NC=CC=C6
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
